Dr. Johan van der Vlag, Dept. of Nephrology and Marjolein Garsen Dept. of Nephrology received a € 100,000 innovation grant from the Dutch Kidney Foundation.
In previous work they showed that the heparan sulfate hydrolyzing enzyme heparanase 1 is essential for the development of proteinuria in experimental diabetic nephropathy. The new innovation grant "Targeting of heparanase 1 activity by heparanase 2 in glomerular diseases" will address the therapeutic potential of heparanase 2 as an endogenous inhibiter of heparanase 1.
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