The image on the cover of the first 2016 issue of Nature Reviews Clinical Oncology was supplied by the laboratory of Experimental Radiotherapy at the Department of Radiation Oncology of the Radboudumc. The image is created by Willem Grootjans, Jasper Lok, Bianca Hoeben, and Johan Bussink. The image shows the tumor architecture of a human xenograft squamous cell carcinoma of the head and neck. After multiple staining several features are visualized; tumor cell proliferation (BrdUrd, green) decreases at increasing distance from the vasculature (purple). Beyond the diffusion distance of oxygen, hypoxic areas are found (pimonidazole, blue).
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