Jenny van der Wijst, theme Renal Disorders, has been awarded a Horizon 2020 Marie Curie Global Fellowship. With this personal grant, Jenny will work together with the Macromolecular Structure Group of Prof. Yifan Cheng at the University of California, San Francisco (UCSF).
The project “CRYO-EM TRPV5” is centered on the structure-function analysis of TRPV5, a distinctive calcium-selective ion channel in the kidney. The aim is to elucidate the TRPV5 protein structure using single particle cryo-electron microscopy, and to unravel functional domains that are involved in channel function at the mechanistic level. Outcomes of this project will contribute to greater understanding of molecular mechanisms causing or predisposing to kidney disease, as well as to future research on other ion channels. There are numerous examples of dysfunction of ion channels causing human diseases (channelopathies).
The Marie Curie fellowships are Europe’s most competitive and prestigious awards, and are aimed at fostering interdisciplinary research and international collaborations. In her project, Jenny will connect her biophysical and biochemical background on ion channel functioning with Prof. Cheng’s world leading expertise in structural biology.
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