Two projects were granted by the Dutch Arthritis Association for the Dept. of Experimental Rheumatology, theme Inflammatory diseases (total amount is € 460,000).
Osteoarthritis is the most prevalent and debilitating joint disease worldwide but no cure has been developed yet. Recent findings show that low grade inflammation within the OA joint may contribute to the pathophysiology and clinical symptoms.
Arjen Blom and Martijn van den Bosch, theme Inflammatory diseases will focus on the involvement of the Wnt-signaling induced protein WISP1 in cartilage destruction in osteoarthritis (OA). The sequence of events that leads to cartilage destruction via WISP1 will be studied both in experimental OA and in a human trial.
Peter van Lent, theme Inflammatory diseases will focus on the therapeutic efficacy of PCSK9 inhibitors in dampening cholesterol driven synovial inflammation and joint destruction in OA. The group of Peter van Lent has significantly contributed in understanding the role of inflammation and joint destruction in osteoarthritis.
Arjen Blom Martijn van den Bosch Peter van Lent
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