Cancer development and immune defense
Theme leader: Joop Jansen
Our primary goals are to gain insight into the molecular, genetic and epigenetic processes that lead to the transformation of normal (stem) cells to malignant cancer cells. The knowledge gained on tumor microenvironment and interactions between the immune system and cancer is translated into the development of specific forms of therapy, targeting the affected molecular pathways, and by using (modified) immune cells targeting the tumor cells.
Keywords: Molecular carcinogenesis; Stem cell Biology; Hemato-oncology; Melanoma; Ovarian Cancer; Immunity against cancer; Dendritic cells; T cells; NK cells; Cellular therapy; Cancer vaccination